20/20 Vision: Chael Sonnen's PED Test Appeal Hearing Should Open Your Eyes To TRT
Here we are a mere 5 or so hours after the California State Athletic Commission hearing for Chael Sonnen's appeal for a failed drug test. While watching the hearing and observing Chael's testimony and the testimony of his doctor, Sonnen claimed that his use of testosterone was for a valid medical reason called Testosterone Replacement Therapy caused by hypogonadism. It is my belief that TRT should not be allowed in the sport of MMA. It is not allowed in the NFL, MLB, and the NBA. It's not even allowed in pro wrestling. This is going to require your thinking caps.
Testosterone replacement therapy is a valid medical treatment for men who have reduced testosterone due to old age, medical illness or past hormonal drug abuse (we'll get back to that in a second). TRT is fine for your average male who isn't in a competitive environment, however inside of a competitive environment, the chance of abuse increases exponentially.
Let's take a trip to the world of professional wrestling shall we. A few years ago, it was common for many wrestlers (such as Chris Benoit) to use TRT as a valid reason to obtain prescriptions. Essentially, all you had to do was show a low testosterone level and a doctor would put you on TRT. So how did you do that? It usually occured one of two ways, either your body's natural testosterone production was permanently damaged due to years of steroid abuse or your temporarily damaged your body's testosterone production by coming off a steroid cycle and getting tested right when your body was still dependent on the exogenous testosterone. You walk into a doctor (usually hand-chosen), he draws your blood, surprise, your levels are low. He prescribes you testosterone and now you have a valid reason to have a high T:E ratio. Of course, in the effort to clean up their company after Chris Benoit's double murder/suicide, they began to crack down, and ultimately ban, prescriptions for testosterone, TRT or not. Yes, you read that right. The WWE, once seen as the Valhalla of steroid usage in the 80's and 90's has outright banned TRT due to its abusive potential.
Back in real fighting, you have a fighter who wants to get a prescription for testosterone. He simply has to undertake those same steps as the pro wrestler. Obtain that artificially low testosterone level, get a doctor to sign off on it and you're good to go. You've got a prescription. Now you've got a cover in case you ever get popped for a bad urine test. I say urine test because no commission tests for blood. What's the difference? Well, with a urine test, all you're going to be able to test is the ratio of testosterone to epitestosterone, whether the testosterone is endo- or exogenous, and the presence of steroid metabolites (to determine what type of steroid it is).
How is that significant? Essentially, you can get popped for a ratio of 20:1 which clearly indicates drug usage, but you can claim that you still test within the normal testosterone ranges. You see, there's a difference between T/E ratio and total testosterone. The urine test can't test for total testosterone (which is why we need blood testing).
So basically you can have three fighters.
- Fighter A (legit need for TRT) - T/E ratio =15:1 (at time of test), total testosterone (at time of test, but not tested for) 800 ng/mL
- Fighter B (guy who wants to cheat) - T/E ratio = 15.1 (at time of test, total testosterone (at time of test, but not tested fr) 5500ng/ML
- Fighter C (guy also wanting to cheat) - T/E ratio of 3.5:1 (at time of test), total testosterone (at time of test, but not tested for) 3500ng/dl*
Now to the commission, it looks like both fighters are the same with the same ratio, but that is not true. Without knowing the total testosterone, you have no idea that Fighter B produces the normal amount of testosterone as indicated by his normal amount of epitestosterone contained and his high testosterone level. Since no blood was actually taken at the time of the test and since drug tests come weeks after the fact, he can claim that he does have a high T:E ratio but that's only because his natural testosterone production is so low and that his total testosterone levels are normal, supplementing it with tests taken by his own doctor. Of course, he knew when those tests were being taken and thus, could alter his testosterone level.
In addition, you also have Fighter C who is taking testosterone as a PED and only does enough to raise his T/E ratio to within the "normal" ratio, but he still has a total testosterone way outside the range of normal which benefits him and places him at an advantage to other fighters.
TRT is subject to abuse by your average male who is not in competition who loves the side effects it provides. Many males on TRT see a resurgence in strength, youth and vigor. They are more aggressive and get back some of that sexual fire they've been missing. A percentage of these men begin to increase their dosages in order to see added benefits. Adding athletics to this equation produces a greater risk for abuse. He's in competition and the desire to win and succeed takes over. Athletes that spend hours a day training, weeks and months preparing, watching their diet, exercising and feeling the effects of the prescribed testosterone, it's like a wonder drug. And that's for athlete without nefarious purpose. The athlete who purposefully sought out a doctor to prescribe testosterone will undoubtedly abuse it.
With the lack of blood testing and and the lack of cooperation between the separate Athletic Commissions, TRT should not be allowed. If the commission is unable to to determine the total testosterone levels through bloodwork, they have no ability to determine whether or not the athlete is abusing. Also, each state seems to have their own standards for approval. Some rely on the fighter's chosen doctor which opens it up to more abuse as you can get your doctor to, within reason, ultimately prescribe anything, ask those in California smoking the finest weed for "legit medical reasons". If all the major sports have banned it and even pro wrestling has, why is it allowed in MMA? When will MMA start taking drug testing seriously?
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the Natural
Didn’t seem so natural once I heard about his TRT a few years ago. Hughes, Hendo, and who knows how many others are allegedly doing this.
Excellent write-up, man.
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A slight caveat to your story, no new TUEs are being given by WWE, but I believe that people who had been granted them before the ban on TUEs was implemented can still use TRT. Of course, TRT is not banned outside of WWE, as no one else does legitimate drug testing.
I was gonna post the same thing. :)
Otherwise an excellent post that absolutely needed to be written after yesterday.
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by David Bixenspan on Dec 3, 2010 3:37 PM EST up reply actions
This is something that disproportionately affects wrestlers, right? Because of the frequent weight-cutting at a young age?
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by Derek Suboticki on Dec 3, 2010 12:06 PM EST reply actions
Didn’t Randy say something about that and his use of TRT? It sounds like familiar reasoning…
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There's no science behind that at all
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by S.C. Michaelson on Dec 3, 2010 12:22 PM EST up reply actions
Dieting, which is probably also taking place during a cut, is notorious for tanking test. Once normal nourishment resumes there is typically a rebound to normal physiological levels. n=1
I imagine repeated accute effects due to cutting could have detrimental effects on long term test production, but that’s purely speculation.
Once I am done having kids, you can bet I’ll be persuing TRT. Why wouldn’t you? But, erein lies the debate, I am not a fighter.
Dieting will not cause normal rates to fall below the normal threshhold and even that science is inconclusive
Fasting definitely decreases testosterone, but not dieting and weight cutting. And I mean prolonged fasting, not “two days before weigh in” fasting.
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by S.C. Michaelson on Dec 3, 2010 3:15 PM EST up reply actions
http://www.thinkmuscle.com/articles/incledon/diet-01.htm
Severe calorie restriction, whether from reduced food intake or imposed by excessive exercise, lowers testosterone (4). While there are no numbers written in stone, a decrease in calories by 15% does not lower T levels (5). This may serve as one factor to consider when planning out a diet strategy. If you cut back too much on your calories, then you risk lowering your T, which can cause you to say goodbye to some of your muscle. The good news is that when refeeding resumes and calorie intake equals calorie expenditure, in most cases, T levels will rise back to normal. The bad news is that if you are engaging in chronic high volume endurance exercise, even extra calories won’t help raise your T levels back to normal.
This link has a nice chart summarizing the effects of both overfeeding and underfeeding
http://www.bodyrecomposition.com/muscle-gain/calorie-partitioning-part-2.html
For those too lazy to click, during underfeeding both free and total test decrease, not to mention a bunch of other physiological changes.
I was gonna break that down piece by piece, but there's no reason to. Why?
Well if you just scrolled down the page, you’d see the section on cycling dieting. Reading that, doesn’t it look a LOT like what MMA fighters do?
Ok, great, I’ve just spent nearly 10 pages making a case for cycling dieting, periods where you alternate a low-calorie intake with a higher calorie intake. in this fashion, you alternate between periods of low calories/carbs with high calories/carbs to alternate between periods of anabolism (tissue building) and catabolism (tissue breakdown). Fundamentally, of course, this is nothing new.
All that stuff about “underfeeding” is something that takes place over a long period of time, not the short time period of weight cutting. If you read what I was disputing, you’ll see that I clearly distinguished the length of time. What you are quoting is someone discussing “underfeeding” as a dietary means on a long term basis. That is not what an MMA fighter does. They cycle calories which he states is the most beneficial.
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by S.C. Michaelson on Dec 3, 2010 4:50 PM EST up reply actions
There is science behind it
The two biggest studies concluded that frequent weight-cutting (i.e. what college wrestlers, boxers and MMA fighters do) can and does decrease testosterone levels
Here is a brief synopsis of the first study in 1993 by Allan Booth, Allan Mazur abd James Dabbs from Penn St:
Salivary testosterone was measured among male college wrestlers (n = 12), some of whom fasted before their matches while others did not. Nonfasting wrestlers had increasing testosterone on the day of their match, whereas fasting wrestlers had decreasing testosterone. Apparently, fasting perturbs the normal pattern of testosterone fluctuation associated with competition. As used here, the term "fasting" does not necessarily imply 100% abstinence from nourishment.
The second study was done in 1998 by Mike Viscardi after some college wrestlers died due to extreme weight cutting. Here is another brief synopsis:
Weight loss of more than two pounds per week must involve either dehydration or starvation and it is exactly this type of weight loss that is most damaging to the body. Among the harmful effects on performance of rapid weight loss are a decrease in strength and power, a decrease in muscle endurance, a decrease in testosterone, and a decrease in isometric endurance and short-term sprinting.
While I agree the answer isn’t taking testosterone to combat the decrease testosterone levels due to weight cutting (just change weight classes so you don’t have to cut as much weight), there is science behind weight cutting and decreased testosterone levels
None of what you said mentions permanent testosterone production losses (only temporary)
Salivary testosterone was measured among male college wrestlers (n = 12), some of whom fasted before their matches while others did not. Nonfasting wrestlers had increasing testosterone on the day of their match, whereas fasting wrestlers had decreasing testosterone. Apparently, fasting perturbs the normal pattern of testosterone fluctuation associated with competition. As used here, the term “fasting” does not necessarily imply 100% abstinence from nourishment.
This says NOTHING about permanent loss of production. That is the crux of the issue. Of course dehydration decreases testosterone levels. And then when you rehydrate it goes back up. You probably should read the actual study and not just post the “synopsis”. You have no idea of the methodology of the test or the definition of the terms. You’ll also look at the sample size of 12. 12. 12? Even still, it says nothing about permanent loss.
The exact same with your second example. Nothing about permanent.
The issue at hand is that due to years of weight cutting, the men’s body doesn’t produce testosterone normally. There’s no science that proves that. At best, it’s an extrapolation of common sense that denying the body of nutrients will adversely affect it.
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by S.C. Michaelson on Dec 3, 2010 9:03 PM EST up reply actions
In addition to what SC already pointed out
It should be noted that in the average healthy male, testosterone levels are continuously variable, and fluctuate considerably not just day-to-day, but throughout the day.
ALSO, and this seems widely misunderstood, but whereas the half-life of testosterone cypionate (the esterified injectable version usual used in the US) has a half-life of 8 days, the half-life of free testosterone in the blood stream is only a few minutes.
All of the following factors/influences are ceteris paribus (that is, holding all other factors constant except the ones being looked at):
—time of day (highest upon waking)
—caloric intake (fasting decreases levels)
—types of calories (fatty foods decrease levels)
—body fat (excess causes lower levels)
—liver issues (liver removes excess estrogen)
—emotional health (a study showed that the loss of a spouse also was associated with a 10-year equivalent (i.e. equivalent to aging 10 years) reduction in testosterone.
—exercise (levels increase significantly immediately after intense exercise)
—exercise level (paradoxically, “overtraining” can lead to decreased levels)
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by The American Ronin on Dec 4, 2010 10:55 AM EST up reply actions
No. There is no link between weight-cutting and loss of testosterone
It does, however, disproportionately affect STEROID USERS.
Separate thought, Randy, Chael, Hendo, All Team Quest, all “TRT” needy. Hmmm.
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by S.C. Michaelson on Dec 3, 2010 12:22 PM EST up reply actions
You should just come out and accuse Randy Couture of cheating
See how that goes over.
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by Derek Suboticki on Dec 3, 2010 9:10 PM EST up reply actions
Nah, I'm not that crazy
I just find it odd that Team Quest all has diminished Test levels.
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by S.C. Michaelson on Dec 3, 2010 9:46 PM EST up reply actions
Well done sir
A couple of things to ponder. First:
—Fighter A (legit need for TRT) – T/E ratio =15:1 (at time of test), total testosterone (at time of test, but not tested for) 800 ng/mL
—Fighter B (guy who wants to cheat) – T/E ratio = 15.1 (at time of test, total testosterone (at time of test, but not tested fr) 5500ng/ML
—Fighter C (using Test Cyp without legitimate medical need) – T/E ratio of 3.5:1 (at the time of test, total testosterone 3500ng/dl). Not flagged for further follow-up testing.
ALSO:
IMO, if a T.U.E. is going to be allowed in MMA (or any sport), it should be contingent on the athlete getting and submitting to the AC docs weekly blood tests showing either total or bioavailable T levels. At the fighter’s expense, and at labs approved by the ACs.
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by The American Ronin on Dec 3, 2010 12:36 PM EST reply actions 1 recs
You're totally right. I should've added a 3rd.
As for your last part, I totally agree.
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by S.C. Michaelson on Dec 3, 2010 1:25 PM EST up reply actions
Nevertheless,
it was a very well done – and timely – piece you did here. Probably like yourself, I am hesitant to put too much out there in a forum like SBN for fear someone might do something stupid with it, but as with so many controversial topics there is so much misinformation and disinformation that shapes the average readers views on the subject.
And FTR, here and elsewhere on this topic, I haven’t been trying at all to nitpick you, its just that you are one of, if not the only, guy I’ve come across here who has done the homework and given the thought needed on this, and I was genuinely seeking answers from you, not trying to split hairs or argue semantics. Of course, given some of our conversations on other topics, its perfectly understandable to view it that way, but in this case I am genuinely seeking more truth…
"Sometimes I wonder if the world is being run by smart people who are putting us on, or by imbeciles who really mean it."
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by The American Ronin on Dec 3, 2010 4:02 PM EST up reply actions
In Need of Clarification
I don’t understand how the T/E ratio is inferior to total testosterone level.
The T/E ratio gives us the ratio of testosterone glucuronide to epitestosterone glucuronide. We know that the epitestosterone level is generally equivalent to the testosterone level (couldn’t find whether this is true among testosterone deficient individuals), therefore, a person should have a 1:1 ratio. We also know that epitestosterone levels are unaffected by exogenous use of testosterone; essentially making epitestosterone a proxy for baseline testosterone. That is why a 4:1 ratio is cause for concern (testosterone levels being 4 times higher than “baseline”). Even if a person was deficient, it would cause both the testosterone level and epitestosterone level to decrease concurrently and would continue to show a 1:1 ratio. Confused about how this test fails to provide the pertinent info.
I fail to see why total testosterone level is a better barometer of usage. I suppose an equivalent method would be to look at an individual’s total testosterone levels over a period of time and determine whether the variance in levels is significantly different from “normal.” This would still be criticized for it’s lack of sensitivity or specificity (apparently like the T/E ratio). I don’t know if I did a good job of explaining myself, but I’d love to hear a response.
idiot
I see what’s going on now. You are saying that for those people who legitimately have low testosterone, any exogenous steroid use will produce a T/E ratio above the allowed amount. There is no way to differentiate between a person who legitimately has low testosterone and an individual using to gain an advantage (once both have begun a course). That is why knowing the total testosterone level ahead of the urinalysis is valuable. And, like you mentioned, someone could lower their total testosterone level artificially through previous cycles; thus, making it appear that they should be treated with replacement therapy.
The funny thing is that one of the causes for being deficient in testosterone is “past hormonal drug abuse.” None of the other causes are relatable to MMA fighters. The allowance for TRT is dubious at best.
Glad to see you were able to get it
The total testosterone is the most important thing. If your total T is above normal, you’re cheating. Unless, in the very ODD occurrence, your total testosterone is above normal and yet your T/E ratio is normal.
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by S.C. Michaelson on Dec 5, 2010 8:38 PM EST up reply actions
After a more thorough read...
I finally got it. I originally thought that you were criticizing the test’s ability to detect a questionable sample. However, now that I am on the same page I have some questions/comments.
First off, is there a range of allowable total testosterone levels? If not, I think it would be extremely difficult to determine what is or is not acceptable. Would you use what is normal among the general population (there is a lack of widely accepted values) or one that is specific to MMA fighters? I’m inclined to believe that fighters have a higher than average total testosterone level (no factual basis). In addition, depending on how the range was constructed, there will be a number of fighters that fall outside of this range due to chance alone.
So, if a “normal” range is not sufficient in determining questionable samples, would we treat a fighter’s most recent sample as the baseline (or average of previous samples)? This wouldn’t be very cost or time efficient. But if using testosterone is an issue in MMA and it gives the user a clear cut advantage, I can see how this would be necessary. Perhaps you could only closely monitor those people who have been cleared for testosterone replacement therapy.
Yes
There is a normal range of total testosterone. The “accepted” values are ranging from about 300 ng/dL to 1000 ng/dL. That is what is “normal” among the average population. Now, there are things that can temporarily raise and lower those rates. Fighters, normally, have the same ranges as regular people, but exercise (and over-exercise) can temporarily raise (and lower) those levels, but not to an extreme.
As for your second part, the odds of a truly clean fighter having outside of normal levels of toial testosterone is rare. It’s a range for a reason. Most men fall in the middle of the range. The range allows for the maximum natural production of testosterone. If a person naturally falls outside that range, then they should at least have a history of tests to back that up. We’re not getting blood tests anytime soon, so establishing baseline test levels is a pie in the sky. But yes, ideally we would.
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by S.C. Michaelson on Dec 6, 2010 10:12 AM EST up reply actions

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